Water → HCID 21107097, compound

Participants

Reaction Steps

A solution of 2-chloro-6-hydroxymethoxybenzaldehyde (2.85 g), 4-methoxyphenylacetic acid (2.54 g) and sodium acetate (3 g) in acetic anhydride (25 mL) was refluxed for 18 h and cooled. Cold water (200 mL) was added. The solids were filtered, washed with water (three times) and ether-hexane (1:1), and dried under high vacuum to give the title compound (2.92 g). 1H NMR (DMSO-d6): 8.03 (s, 1H), 7.68 (d, 2H, J=8.7 Hz), 6.98 (d, 2H, J=8.7 Hz), 6.94 (d, 1H, J=1.8 Hz), 6.77 (d, 1H, J=1.8 Hz), 3.87 (s, 6H).

Provenance & Evidence