HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dimethoxyethane → 3-(3,5-Di-t-butyl-4-hydroxyphenyl)-3-methoxybenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-2,6-di-tert-butylphenol | HCID 70829 | — |
| Reactant | 5-Formyl-2-methoxyphenylboronic acid | HCID 2734367 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(3,5-Di-t-butyl-4-hydroxyphenyl)-3-methoxybenzaldehyde | HCID 22268285 | 61% |
Reaction Steps
The intermediate 3-(3,5-di-t-butyl-4-hydroxyphenyl)-3-methoxybenzaldehyde was prepared in a manner similar to the procedure described in Example 1 b using 4-bromo-2,6-di-t-butylphenol (0.50 g, 1.75 mmol), 2-methoxy-5-formylphenyl boronic acid (0.315 g, 1.75 mmol), tetrakis(triphenylphosphine)palladium(0) (0.20 g, 0.175 mmol), K2CO3 (0.95 g, 7.0 mmol), dimethoxyethane (15 mL) and H2O (1 mL); 367 mg, 61% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07226940B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-9c36af6ebc60449e8052fecfd94683e7 |
| Source note | uspto-grants-2007_06 |