2-(3-Bromophenyl)-1,3-dioxolane → HCID 11772109, compound

Participants

Reaction Conditions

Reaction Steps

To a dry flask containing 2-(3-bromophenyl)-1,3-dioxaolane (1.0 mL; 1.0 eq) and amine 6, (1.6 mL; 1.2 eq) in dry toluene (20 mL) was added BINAP (124 mg; 0.03 eq), palladium acetate (30 mg; 0.02 eq) and sodium tert-butoxide (0.89 g; 1.4 eq). The reaction was heated to 80° C. under nitrogen. After 2 hours the solution was cooled, diluted with ethyl acetate and washed with one portion water. The organics were dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography, eluting with 5% methanol in dichloromethane. An orange oil was obtained (2.035 g; 91% yield).

Provenance & Evidence