反应详情

A solution of the compound of formula (5) (3.70 g, 0.016 mol), isopropyl amine (7.46 ml, 0.127 mol) in methanol (20 ml) was stirred under reflux for 2 hours and then concentrated. The residue was partitioned between chloroform and water. The organic layer was dried over anhydrous sodium sulphate, filtered and concentrated. The residue was crystallized from pet ether to afford compound of formula (1) as a white solid 3.47 g (75%) mp 52–53° C.

1. temperatureunder reflux for 2 hours
2. concentrationconcentrated
3. customThe residue was partitioned between chloroform and water
4. dry with materialThe organic layer was dried over anhydrous sodium sulphate
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was crystallized from pet ether