2-Amino-5-chlorobenzophenone → N-(2-benzoyl-4-chloro-phenyl)-4-pyrazol-1-yl-benzenesulfonamide

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].[N:17]1([C:22]2[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=2)[CH:21]=[CH:20][CH:19]=[N:18]1>>[C:9]([C:3]1[CH:4]=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=1[NH:1][S:28]([C:25]1[CH:24]=[CH:23][C:22]([N:17]2[CH:21]=[CH:20][CH:19]=[N:18]2)=[CH:27][CH:26]=1)(=[O:29])=[O:30])(=[O:10])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

反応物 2

HCID 128702-Amino-5-chlorobenzophenone

HCID 27764754-(1H-pyrazol-1-yl)benzene-1-sulfonyl chloride

生成物 1

HCID 11487442N-(2-benzoyl-4-chloro-phenyl)-4-pyrazol-1-yl-benzenesulfonamide

実験手順

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-Amino-5-chloro-phenyl)-phenyl-methanone and 121 mg of 4-Pyrazol-1-yl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 6.47 (m, 1H), 7.25 (m, 2H), 7.30–7.35 (m, 3H), 7.41 (m, 1H), 7.49–7.55 (m, 3H), 7.67–7.72 (m, 3H), 7.75–7.78 (m, 2H), 9.62 (s, 1H). MS: m/z 438.9 (M++1).

出典と根拠

ORDレコード: ord-cdf055d6ad4a4347bb7d28b03f31e65d
出典データセット: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07227035B2

反応ノート

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