Hydrochloric Acid → HCID 11339067, compound

Participants

Reaction Steps

This compound was prepared generally following the procedure above for example 22 using (−)-N-[3-(5-fluoro-1H-indol-3-yl)propyl]-2,3-dihydro-1H-pyrano[3,2-f]quinolin-2-amine (example 21b) as starting material. It was converted to the HCl salt by dissolution in ethyl acetate and addition of 1M HCl/Et2O (2.4 eq) to generate (+)-N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-propyl-2,3-dihydro-1H-pyrano[3,2-f]quinolin-2-amine bis-hydrochloride salt as a yellow solid: mp 106° C./dec. [α]D25=+38.0° (c=1% solution, DMSO). MS ESI m/z 418 [M+H]+. Elemental Analysis for C26H28FN3O·2.00 HCl; Calculated: C, 63.67; H, 6.17; N, 8.57. Found: C, 63.32; H, 6.39; N, 8.27.

Provenance & Evidence