Hydrochloric Acid → HCID 11486499, compound

Participants

Reaction Steps

This compound was prepared generally following the procedure above for example 22 using N-[2-(5-fluoro-1H-indol-3-yl)ethyl-2,3-dihydro-1H-pyrano[3,2-f]quinolin-2-amine (example 25) as starting material. It was converted to the HCl salt by dissolution in ethyl acetate and addition of 1M HCl/Et2O (2.4 eq) to generate N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-N-propyl-2,3-dihydro-1H-pyrano[3,2-f]quinolin-2-amine bis-hydrochloride salt as a yellow solid: mp 67° C. MS ESI m/z 404 [M+H]+. Elemental Analysis for C25H26FN3O·2.00 HCl·1.25 H2O; Calculated: C, 60.18; H, 6.16; N, 8.42. Found: C, 60.49; H, 6.35; N, 8.16.

Provenance & Evidence