Hydrochloric Acid → HCID 11373435, compound

Participants

Reaction Steps

This compound was prepared generally following the procedure above for example 22 using N-[3-(5-fluoro-1H-indol-3-yl)propyl]-3,4-dihydro-2H-pyrano[2,3-f]quinolin-3-amine (example 27) as starting material. It was converted to the HCl salt by dissolution in ethyl acetate and addition of 1M HCl/Et2O (2.4 eq) to generate N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-propyl-3,4-dihydro-2H-pyrano[2,3-f]quinolin-3-amine bis-hydrochloride salt as a yellow solid: mp 134° C./dec. MS (ESI) m/z 418 [M+H]+. Elemental Analysis for C26H28FN3O·2.00 HCl·0.75 H2O; Calculated: C, 61.97; H, 6.30; N, 8.34. Found: C, 62.09; H, 6.60; N, 8.20.

Provenance & Evidence