Hydrochloric Acid → HCID 11293369, compound

Participants

Reaction Steps

This compound was prepared generally following the procedure above for example 22 using N-[4-(5-fluoro-1H-indol-3-yl)butyl]-3,4-dihydro-2H-pyrano[2,3-f]quinolin-3-amine (example 29) as starting material. It was converted to the HCl salt by dissolution in ethyl acetate and addition of 1M HCl/Et2O solution (2.4 eq) to generate N-[4-(5-fluoro-1H-indol-3-yl)butyl]-N-propyl-3,4-dihydro-2H-pyrano[2,3-f]quinolin-3-amine bis-hydrochloride salt as a light brown solid: mp 164° C./dec. MS ESI m/z 432 [M+H]+.

Provenance & Evidence