5-Chloro-1-benzofuran-2-carboxylic acid → 5-Chloro-1-benzofuran

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil. Gas-chromatography electron-ionisation spectrum: Found: M+ 152, Rt 5.72 min

Provenance & Evidence