Sulfuric Acid → HCID 21107238, compound

HRID 1765769Notes

Reaction equation

HRID 1765769 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([CH3:14])(O)[CH3:12])=[C:4]([O:15][CH3:16])[CH:3]=1.S(=O)(=O)(O)O>O>[Br:1][C:2]1[CH:7]=[C:6]2[C:5]([CH2:8][CH2:9][CH2:10][C:11]2([CH3:14])[CH3:12])=[C:4]([O:15][CH3:16])[CH:3]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 21107192HCID 21107192, compound2×

Product 1

HCID 21107238HCID 21107238, compoundYield 84.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-(4-Bromo-2-methoxy-phenyl)-2-methyl-pentan-2-ol (Intermediate 62, 7.3 g, 24.6 mmol) was treated with 85% sulfuric acid (25 mL) at ambient temperature. After 30 minutes, the reaction mixture Was diluted with cold water and extracted with diethyl ether. The organic phase was washed with water and brine, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product (5.6 g, 83%).

Workup

  1. extractionextracted with diethyl ether
  2. washThe organic phase was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-677af20bd656487ba6dd1167321bcd12
Source dataset
uspto-grants-2007_06
Patent number
US07226951B2

Reaction notes

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