HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-isopropylbenzene → (S)-2-(3-Isopropyl-phenylamino)-3-(3,4,5-trimethoxyphenyl)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-isopropylbenzene | HCID 138499 | — |
| Reactant | (S)-2-(Biphenyl-3-ylamino)-3-(3,4,5-trimethoxy-phenyl)-propionic acid | HCID 11384247 | — |
| Product | (S)-2-(3-Isopropyl-phenylamino)-3-(3,4,5-trimethoxyphenyl)-propionic acid | HCID 67492445 | — |
Reaction Steps
The title compound is prepared as described for (S)-2-(Biphenyl-3-ylamino)-3-(3,4,5-trimethoxy-phenyl)-propionic acid (example 1) but using 1-bromo-3-isopropylbenzene (Lancaster). Purification by MPLC (CH3CN/H2O/TFA) afforded the title compound; ES-MS: 374.1 [M+H]+; HPLC: single peak at tR=8.95 min (System 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229617B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-6ec5ea10d56348ce9c1bfa495c3d0188 |
| Source note | uspto-grants-2007_06 |