2-(Trifluoromethyl)benzylamine → HCID 178506139, compound

Participants

Reaction Steps

A mixture of 1.1 g (7.5 mmol) 1H-benzimidazole-2-carbaldehyde (Fluorochem), 1.3 g (7.5 mmol) 2-trifluoromethylbenzylamine and 1 drop glacial acetic acid in 10 ml methanol was stirred at room temperature for 72 hours. The resulted yellow solution was evaporated to c.a. 2–3 ml, cooled to −40° C. and the formed solid filtered. It was washed with methanol/water mixture (1/2) and dried under reduced pressure. Yield—1.96 g (86.4%). 1H NMR (250 MHz, D2-DCM), δ: 5.03 (s, 2H), 7.28–7.69 (m, 8H), 8.46 (s, 1H).

Provenance & Evidence