Methanol → HCID 69331780, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-methoxy-4-methyl-D-phenylalanine hydrochloride (1.75 g) in methanol (8 ml) was added dropwise thionyl chloride (0.7 ml) at room temperature over 10 minutes. The total mixture was stirred at 40 to 50° C. for 2 hours and thionyl chloride (0.7 ml) was added further to the mixture. The total mixture was stirred for further 1 hour and the solvent was evaporated under reduced pressure. The produced solid substance was triturated with diisopropyl ether and collected by filtration to give 3-methoxy-4-methyl-D-phenylalanine methyl ester hydrochloride (1.70 g) in the form of colorless crystals.

Provenance & Evidence