Tert-butyl 3-oxopyrrolidine-1-carboxylate → HCID 58593064, compound

HRID 1765996Notes

Reaction equation

HRID 1765996 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C:10](=O)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:14]1([C:17]2[CH:18]=[C:19]([C:36]([OH:38])=[O:37])[C:20](=[O:35])[N:21]3[C:26]=2[C:25]([CH3:27])=[C:24]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[C:23]([F:34])=[CH:22]3)[CH2:16][CH2:15]1.NCC1CCN(C2C(F)=CN3C(C=2C)=C(C2CC2)C=C(C(O)=O)C3=O)C1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([N:31]2[CH2:32][CH2:33][N:28]([C:24]3[C:23]([F:34])=[CH:22][N:21]4[C:26]([C:25]=3[CH3:27])=[C:17]([CH:14]3[CH2:16][CH2:15]3)[CH:18]=[C:19]([C:36]([OH:38])=[O:37])[C:20]4=[O:35])[CH2:29][CH2:30]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 471360Tert-butyl 3-oxopyrrolidine-1-carboxylateHCID 479552HCID 479552, compoundHCID 483965HCID 483965, compound

Product 1

HCID 58593064HCID 58593064, compound

Procedure

The title compound was prepared as described in Step 1 of Example 9 (1974) except 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester was used in place of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester and 1-cyclopropyl-7-fluoro-9-methyl-4-oxo-8-piperazin-1-yl-4H-quinolizine-3-carboxylic acid was used in place of (8-(3-aminomethyl-pyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid.

Sources & evidence

ORD record
ord-0a38c1330a4949fb854a2d9940fc1eb4
Source dataset
uspto-grants-2007_06
Patent number
US07229996B2

Reaction notes

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