Acetic Anhydride → HCID 21108196, compound

HRID 1766027Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][O:17][C:18]3[CH:28]=[CH:27][C:21]4[CH2:22][CH2:23][CH2:24][NH:25][CH2:26][C:20]=4[CH:19]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:29](OC(=O)C)(=[O:31])[CH3:30]>>[ClH:1].[C:29]([N:25]1[CH2:24][CH2:23][CH2:22][C:21]2[CH:27]=[CH:28][C:18]([O:17][CH2:16][CH2:15][CH2:14][N:11]3[CH2:12][CH2:13][CH:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)[CH2:9][CH2:10]3)=[CH:19][C:20]=2[CH2:26]1)(=[O:31])[CH3:30]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 58884676HCID 58884676, compound

Product 1

HCID 21108196HCID 21108196, compound

Procedure

Using 8-[3-[4-(4-chlorophenyl)-1-piperidinyl]propoxy]-2,3,4,5-tetrahydro-1H-2-benzazepine obtained in Example 207 and acetic anhydride, the title compound was obtained as colorless amorphous powder by the same procedure as in Example 17.

Sources & evidence

ORD record: ord-597967c67e8b4360a732c0e7a0afc6f1
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07229986B2

Reaction notes

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