4-Nitrophenyl chloroformate → HCID 69037811, compound

Participants

Reaction Steps

tert-Butyl 5-amino-2-phenyl-4-(3-aminophenyl)-thieno[2,3-d]pyrimidine-6-carboxamide (example 31(g), 2.0 g) was dissolved in dry CH2Cl2 (20 ml). Subsequently, a solution of p-nitro-phenyl chloroformate (520 mg) in dry CH2Cl2 (10 ml) was added dropwise and the reaction mixture was stirred at room temperature. After 3 h, the reaction mixture was washed with H2O. The organic layer was dried (MgSO4) and concentrated under reduced pressure.

Provenance & Evidence