Carbon tetrabromide → HCID 17951766, compound

Participants

Reaction Steps

To a 100 ml round-bottom flask equipped with a magnetic stir-bar and N2 inlet was added {5-[2-(4-Methoxy-3-methyl phenyl)ethyl]-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanol (0.708 g, 1.74 mmoles, 1 eq), CH2Cl2 (20 ml), carbon tetrabromide (0.634 g, 1.91 mmoles, 1.1 eq) and triphenylphosphine (0.501 g, 1.91 mmoles, 1.1 eq) in that order. The reaction was stirred overnight at which time it was diluted with CH2Cl2 and washed with H2O, brine, dried over Na2SO4, concentrated in vacuo and purified via silica gel chromatography to yield 573 mg (70%) of product.

Provenance & Evidence