N,N-Dimethylaniline → 2,6-Di(propan-2-yl)phenyl carbonochloridate

Participants

Reaction Conditions

Reaction Steps

Phosgene (13 mL, 20% in toluene) was added to propofol (3.6 g, 20 mmol) under a nitrogen atmosphere. The mixture was cooled to 0° C. and N,N-dimethylaniline (3.3 mL, 26 mmol) was added dropwise. The reaction mixture was allowed to warm to room temperature slowly and stirred for 14 h. The solvent was removed in vacuo. The crude product was carried to next step without further purification.

Provenance & Evidence