反应详情

50 cm3 of thionyl chloride were added to 3.4 g (11.8 mmol) of 1-(quinolin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid at a temperature in the region of 20° C. under an argon atmosphere. After stirring at reflux for 2 h, the reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa), triturated twice in succession with 30 cm3 of dichloromethane and then concentrated to dryness under reduced pressure (2.7 kPa) to give 11.8 mmol of 3-chlorocarbonyl-1-(quinolin-4-yl)-1H-pyrrolo[2,3-b]pyridine hydrochloride in the form of a yellow powder which was used directly in the following stage.

1. temperatureat reflux for 2 h
2. concentrationthe reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa)
3. customtriturated twice in succession with 30 cm3 of dichloromethane
4. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)