Potassium Carbonate → HCID 21109918, compound

Participants

Reaction Steps

A mixture of 0.13 g (0.008662 mol) of 4-acetylamino-3-bromobenzenebutanoic acid and 10 ml of conc. hydrochloric acid was refluxed for 24 hours. The colourless, needle-shaped crystals of Rf 0.53 (eluant: dichloromethane/methanol 9/1 v/v) precipitated after cooling were identified by spectroscopy as the hydrochloride of the desired 4-amino-3-bromobenzenebutanoic acid. The crystals were dissolved in a little water, and the solution formed was adjusted to pH 6 using concentrated potassium carbonate solution. The precipitate was suction filtered, washed with water and dried in a circulating air dryer at 60° C. Yield: 1.35 g (60% of theoretical).

Provenance & Evidence