Ammonia → 5-methoxy-2-nitro-N-[1-(phenylmethyl)-4-piperidinyl]-benzeneacetamide

Participants

Reaction Conditions

Reaction Steps

9.24 g (56.98 mmol) of N,N′-carbonyldiimidazole were added to a solution of 12.0 g (56.8 mmol) of 5-methoxy-2-nitrobenzene-acetic acid in 100 ml of tetrahydrofuran and the mixture was stirred for 40 minutes at a reaction temperature of 40° C. After the addition of 11.6 g (56.88 mmol) of 1-(phenylmethyl)-4-piperidineamine the mixture was heated to 40° C. for another hour. The reaction mixture was concentrated by evaporation in vacuo, the solid residue was digested with 50 ml of water and tert.butylmethylether, suction filtered and dried in a circulating air dryer at 50° C. 19.9 g (91% of theoretical) of pale yellow crystals were obtained, Rf 0.6 (eluant: dichloromethane/EE/cyclohexane/methanol/conc. ammonia 300/80/25/25/3 v/v/v/v/v).

Provenance & Evidence