反应详情

The nitro intermediate (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (50 mg) until completion as indicated by TLC or LC-MS, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford 4-(4′-fluoro-3′-trifluoromethyl-phenoxy)aniline, which was used directly for further transformation without purification (overall yield: 95%).

1. filtrationThe reaction mixture was then filtered
2. customto remove the catalyst
3. customThe solvent was removed in vacuuo