Methane → HCID 21109849, compound

Participants

Reaction Steps

A solution of 0.48 g (1.153 mmol) of 3-{1-[4-(4-cyanophenyl)-1,4-dioxobutyl]-4-piperidinyl}-3,4-dihydro-2(1H)-quinazolinone (Item no. 73) and 1.15 ml of 1N hydrochloric acid in 100 ml of methanol was hydrogenated at ambient temperature under 3 bar of pressure in the presence of 0.25 g of 10% palladium on active charcoal until the uptake of hydrogen had ended. The mixture was freed from catalyst and solvent and yielded 0.27 g (58% of theoretical) of a colourless substance, Rf 0.30 (El A). IR (KBr): 1662.5 (C═O) MS: M+406; ESI: (M+H)+=407

Provenance & Evidence