Pyridinium chloride → HCID 17980101, compound

HRID 1766225Notes

Reaction equation

HRID 1766225 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:7][NH:8]2)=[CH:4][C:3]=1[O:18]C.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]3[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]3)=[CH:7][NH:8]2)=[CH:4][C:3]=1[OH:18]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 17980102HCID 17980102, compound

Product 1

HCID 17980101HCID 17980101, compoundYield 93%

Procedure

By a method similar to Preparation 8, using 6-fluoro-5-methoxy-3-(1-methylpiperidin-4-yl)-1H-indole (0.410 g) and 25 g of pyridine hydrochloride gave 0.360 g (93%) the title compound: Mass spectrum (ion spray): m/z=248 (M).

Workup

  1. customBy a method similar to Preparation 8

Sources & evidence

ORD record
ord-f325a073f2d74ef18b203772e30053b4
Source dataset
uspto-grants-2007_06
Patent number
US07230011B2

Reaction notes

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