HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → 1-Ethyl-5-methoxy-7-methyl-3-(1-methylpiperdin-4-yl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | Potassium hydride | HCID 82127 | — |
| Reactant | 5-methoxy-7-methyl-3-(1-methylpiperidin-4-yl)-1H-indole | HCID 17980098 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Ethyl-5-methoxy-7-methyl-3-(1-methylpiperdin-4-yl)-1H-indole | HCID 69432286 | 704.3% |
Reaction Steps
By a method similar to Preparation 26, using 5-methoxy-7-methyl-3-(1-methylpiperidin-4-yl)-1H-indole (5.81 mmole, 1.5 g) in THF (100 mL), 35% potassium hydride (5.81 mmole, 0.665 g), 18-crown-6 (0.58 mmole, 0.153 g), and iodoethane (5.81 mmole, 0.906 g, 0.464 mL) afforded 1.17 g (70%) of the title compound: mass spectrum (ion spray): m/z=287 (M+1); Calculated for C18H26N2O-0.1 H2O: C, 75.01; H, 9.16; N, 9.72. Found: C, 75.10; H, 9.01; N, 9.79.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230011B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-105ba5f04cc449dc99d9dec599df9203 |
| Source note | uspto-grants-2007_06 |