6-Methoxyquinoline → Quinoline, 1,2,3,4-tetrahydro-6-methoxy-

Participants

Reaction Conditions

Reaction Steps

6-Methoxyquinoline (48 g, 0.30 mol) was dissolved in 500 mL methanol and mix with PtO2 (12 g, 52.8 mmol), the mixture was put in a Parr shaker heated to 40° C. under hydrogen (40 psi (275 kPa)) for 24 h. The reaction was cool to room temperature, released the pressure, and then removed the catalyst. The solvent was concentrated resulting the title compound: 1H NMR (300 MHz, CDCl3) 1.90-1.97 (m, 2), 2.75 (t, 2H, J=6.4 Hz), 3.25 (t, 2H, J=5.5 Hz), 3.72 (s, 3H), 6.44-6.60 (m, 3H). cl PREPARATION 36

Provenance & Evidence