HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1766249Generated: October 31, 2026
Benzenesulfonyl chloride → Benzenesulfonic acid 7-bromo-1H-indol-5-yl ester
https://huagongshe.com/reaction/1766249
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 17980131 | HCID 17980131 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Benzenesulfonic acid 7-bromo-1H-indol-5-yl ester | HCID 86592475 | — |
Reaction Steps
Combine 7-bromo-5-hydroxy-1H-indole and 0.2 N NaOH (1.1 eq.) in THF. Cool to about 0° C. before adding benzenesulfonyl chloride (1.10 eq.). Allow the reaction mixture to warm to ambient temperature. After 8 hours, pour into ethyl acetate, wash with water, dry the organic layer over Na2SO4 and concentrate. Purify to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07230011B2 |
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| Source dataset | uspto-grants-2007_06 |
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| ORD ID | ord-2d00920179cb4cf3bb20f2c6379eace7 |
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| Source note | uspto-grants-2007_06 |
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