HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dichlorobenzoic acid → HCID 21110281, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dichlorobenzoic acid | HCID 5784 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-amino-2,3-dihydro-1H-inden-1-one | HCID 312890 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | HCID 21110281 | HCID 21110281 | 35% |
Reaction Steps
Reaction of 2,5dichlorobenzoic acid (287 mg, 1.50 mmol) in thionyl chloride (3.5 mL) then with 5-amino-indan-1-one (74 mg, 0.50 mmol) in presence of triethylamine (0.5 mL) in THF (6 mL) according to method B gave 2,5-dichloro-N-(1-oxo-indan-5-yl)-benzamide (33 mg, 0.09 mmol, 35% yield) as a green powder after purification by chromatography on silica gel (eluent: DCM).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230020B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-e654edc357d64254bc2220293983b61d |
| Source note | uspto-grants-2007_06 |