HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 58885273, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3,5-Dichlorobenzoyl chloride | HCID 76191 | — |
| Reactant | 5-amino-2,3-dihydro-1H-inden-1-one | HCID 312890 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58885273 | HCID 58885273 | 144% |
Reaction Steps
Reaction of 5-amino-indan-1-one (73 mg, 0.50 mmol) in THF (6 mL) with 3,5-dichlorobenzoyl chloride (136 mg, 0.65 mmol) in presence of triethylamine (90 μL, 0.65 mmol) according to method A gave biphenyl-4-carboxylic acid (1-oxo-indan-5-yl)-amide (115 mg, 0.36 mmol, 72% yield) as a brown powder after purification by washing the crude product with ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230020B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-f887e18207b54fadb068c9eeaae8218a |
| Source note | uspto-grants-2007_06 |