HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(1-oxo-indan-5-yl)-4-propyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Propylbenzoyl chloride | HCID 104293 | — |
| Reactant | 5-amino-2,3-dihydro-1H-inden-1-one | HCID 312890 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(1-oxo-indan-5-yl)-4-propyl-benzamide | HCID 21110320 | 64% |
Reaction Steps
Reaction of 5-amino-indan-1-one (75 mg, 0.50 mmol) in THF (6 mL) with 4-propylbenzoyl chloride (108 μL, 0.65 mmol) in presence of triethylamine (90 μL, 0.65 mmol) according to method A gave N-(1-oxo-indan-5-yl)-4-propyl-benzamide (94 mg, 0.32 mmol, 64% yield) as a white powder after purification on silica gel (eluent EtOAc/DCM 0/10 to 1/9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230020B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-d5521cb92ef24f18a624e5c732e95329 |
| Source note | uspto-grants-2007_06 |