HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Anisoyl chloride → 4-methoxy-N-(1-oxo-indan-5-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Anisoyl chloride | HCID 7477 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-amino-2,3-dihydro-1H-inden-1-one | HCID 312890 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-methoxy-N-(1-oxo-indan-5-yl)-benzamide | HCID 21110304 | 76% |
Reaction Steps
Reaction of 5-amino-indan-1-one (73 mg, 0.50 mmol) in THF (6 mL) with p-anisoyl chloride (88 μL, 0.65 mmol) in presence of triethylamine (90 μL, 0.65 mmol) according to method A gave 4-methoxy-N-(1-oxo-indan-5-yl)-benzamide (107 mg, 0.38 mmol, 76% yield) as a yellow powder after purification by chromatography on silica gel (eluent EtOAc/DCM 0/10 to 2/8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230020B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-cffcebc04bf045eeae000b1f7ebece0c |
| Source note | uspto-grants-2007_06 |