HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(4-benzoylphenyl)-4-biphenylcarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Aminobenzophenone | HCID 14346 | — |
| Reactant | 4-Phenylbenzoyl chloride | HCID 84151 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-benzoylphenyl)-4-biphenylcarboxamide | HCID 1590830 | 63.5% |
Reaction Steps
Reaction of 4-aminobenzophenone (102 mg, 0.52 mmol) in THF (6 mL) with 4-biphenylcarbonyl chloride (143 mg, 0.65 mmol) in presence of triethylamine (90 μL, 0.65 mmol) according to method A gave biphenyl-4-carboxylic acid (4-benzoyl-phenyl)-amide (125 mg, 0.33 mmol, 63% yield) as a yellow powder after purification by crystallisation in DCM/EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230020B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-de9d22677a394f28b24e1e29749a0c8c |
| Source note | uspto-grants-2007_06 |