2,5-Dichlorobenzoic acid → HCID 21110330, compound

Participants

Reaction Steps

Reaction of 2,5-dichlorobenzoic acid (300 mg, 1.50 mmol) in thionyl chloride (3.5 mL) then with 4-aminobenzophenone (100 mg, 0.51 mmol) in presence of triethylamine (90 μL) in THF (6 mL) according to method B gave N-(4-benzoyl-phenyl)-2,5-dichloro-benzamide (160 mg, 0.43 mmol, 84% yield) as a off-white powder after purification by chromatography on silica gel (eluent:EtOAc/exane 1/9 to 3/7).

Provenance & Evidence