HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dichlorobenzoic acid → 2,5-dichloro-N-(4-chloro-2-methyl-benzothiazol-5-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dichlorobenzoic acid | HCID 5784 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Chloro-2-methylbenzo[d]thiazol-5-amine | HCID 11217857 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | 2,5-dichloro-N-(4-chloro-2-methyl-benzothiazol-5-yl)-benzamide | HCID 21110272 | 52% |
Reaction Steps
Reaction of 2,5-dichlorobenzoic acid (145 mg, 0.76 mmol) in thionyl chloride (5 mL) then with 4-chloro-2-methyl-benzothiazol-5-ylamine (50 mg, 0.25 mmol) in presence of triethylamine (0.5 mL) in THF (2 mL) according to method B gave 2,5-dichloro-N-(4-chloro-2-methyl-benzothiazol-5-yl)-benzamide (50 mg, 0.13 mmol, 52% yield) as a white powder after purification by chromatography on silica gel(eluent: DCM).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230020B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-2808113753c240eb9c55d2c9d55b5975 |
| Source note | uspto-grants-2007_06 |