HuagongsheHuagongshe Chemistry Print Report · For research reference only
Felbinac → HCID 58885281, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Felbinac | HCID 3332 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Chloro-2-methylbenzo[d]thiazol-5-amine | HCID 11217857 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58885281 | HCID 58885281 | 60% |
Reaction Steps
Reaction of 4-biphenylacetic acid (160 mg, 0.76 mmol) in thionyl chloride (1 mL) then with 4-chloro-2-methyl-benzothiazol-5-ylamine (50 mg, 0.25 mmol) in presence of triethylamine (0.5 mL) in THF (2 mL) according to method B gave biphenyl-4-carboxylic acid (4-chloro-2-methyl-benzothiazol-5-yl)-amide (60 mg, 0.15 mmol, 60% yield) as a pink powder after purification by chromatography on silica gel (eluent: DCM).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230020B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-6b187cddb5c14f57a8b227464ef3cf74 |
| Source note | uspto-grants-2007_06 |