HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Aminoacetophenone → N-(4-acetylphenyl)-4-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Aminoacetophenone | HCID 7468 | — |
| Reactant | p-Anisoyl chloride | HCID 7477 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-acetylphenyl)-4-methoxybenzamide | HCID 721316 | 75% |
Reaction Steps
Reaction of 4-aminoacetophenone (74 mg, 0.55 mmol) in THF (6 mL) with p-anisoyl chloride (90 mg, 0.65 mmol) in presence of triethylamine (90 μL, 0.65 mmol) according to method A gave N-(4-acetyl-phenyl)-4-methoxy-benzamide (110 mg, 0.41 mmol, 75% yield) as a white powder after washing by dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230020B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-e5034d538777400d9bc552c64f1e2b3e |
| Source note | uspto-grants-2007_06 |