反应详情

3-Aminocrotonitrile (1.0 g, 12.2 mmol), 3-trifluoromethylaniline (2.0 g, 12.4 mmol), and acetic acid (1.23 g, 20.5 mmol) are dissolved in water (8 ml). The reaction mixture is stirred at room temperature for 30 minutes. The mixture is extracted with toluene three times and the organic phase is dried over sodium sulfate. The solvent is removed in vacuo and the residue is purified by column chromatography on silica with cyclohexane/ethyl acetate mixtures as eluent.

1. extractionThe mixture is extracted with toluene three times
2. dry with materialthe organic phase is dried over sodium sulfate
3. customThe solvent is removed in vacuo
4. customthe residue is purified by column chromatography on silica with cyclohexane/ethyl acetate