HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malononitrile → Ethyl 6-amino-5-cyano-4-(4-cyanophenyl)-2-methyl-1-[3-(trifluoromethyl)phenyl]-1,4-dihydro-3-pyridinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malononitrile | HCID 8010 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Cyanobenzaldehyde | HCID 66042 | — |
| Reactant | Ethyl-3-{[3-(trifluoromethyl)phenyl]amino}-2-butenoate | HCID 68427624 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 6-amino-5-cyano-4-(4-cyanophenyl)-2-methyl-1-[3-(trifluoromethyl)phenyl]-1,4-dihydro-3-pyridinecarboxylate | HCID 21110182 | — |
Reaction Steps
The compound is prepared as described for Example 14A with 100 mg (0.37 mmol) of the compound of Example 1A, 48 mg (0.37 mmol) 4-formylbenzonitrile, 24.18 mg (0.37 mmol) malononitrile and 3.12 mg (3.6 μl, 0.04 mmol) piperidine in 2 ml ethanol. The product is purified by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230017B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-f218822f779b456f8730e41c6add25ef |
| Source note | uspto-grants-2007_06 |