HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 21110163, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 3-chloro-3-oxopropionate | HCID 118931 | — |
| Reactant | Tert-butyl 3-aminopropanoate hydrochloride | HCID 16218890 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 21110163 | HCID 21110163 | — |
Reaction Steps
10 g (55.05 mmol) tert.-butyl β-alaninate hydrochloride are dissolved in 50 ml tetrahydrofuran, and 11.14 g (110.1 mmol) triethylamine and 5.53 g (36.7 mmol) ethyl 3-chloro-3-oxopropanoate are added at 0° C. The reaction mixture is stirred at room temperature for 18 hours. The solvent is removed in vacuo and the product is isolated by column chromatography (silica, eluent dichloromethane/methanol 100:1→50:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230017B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-c90f6bca2af049598aa85d1ffdaac48d |
| Source note | uspto-grants-2007_06 |