Sulfuric acid magnesium salt (1:1) → HCID 21110148, compound

Participants

Reaction Steps

To a solution of allyl 2-acetyl-3-(4-cyanophenyl)-5-oxo-5-{[3-(trifluoromethyl)-phenyl]amino}pentanoate (Example 53A) (12.60 g, 27.49 mmol) in 400 ml ethanol are added Amberlyst-15 (12.60 g) and magnesium sulphate (25.20 g, 209.4 mmol). The reaction mixture is stirred at reflux temperature overnight and then cooled to room temperature. The solids are removed by filtration using a pad of kieselgur. The solvent is removed in vacuo and the crude material is purified by column chromatography on silica gel (eluent dichloromethane).

Provenance & Evidence