HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 11951297, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 21109700 | HCID 21109700 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 11951297 | HCID 11951297 | 85% |
Reaction Steps
A mixture of 23.5 mg (0.072 mmol) 5-(2,4-dichloro-phenyl)-6-propoxy-nicotinic acid, 29 mg (0.09 mmol) TBTU, 10 mg (0.086 mmol) (1R,2R)-2-amino-cyclohexanol and 47.8 mg (0.37 mmol) DIPEA in 1 DMF was shaken at room temperature over night. Acetic acid was added and purified by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile/water/HCOOH. The combined product fractions were evaporated to yield 24.9 mg (85%) of the title compound. MS (m/e): 423.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-5e3aac54fb884e5c8b533024d5614b94 |
| Source note | uspto-grants-2007_06 |