2-Methoxyethanol → HCID 11951299, compound

HRID 1766448Notes

Reaction equation

HRID 1766448 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[C:8](Br)[C:7](Cl)=[N:6][CH:5]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1B(O)O.[NH2:24][CH2:25][C:26]([CH:29]1[CH2:31][CH2:30]1)([OH:28])[CH3:27].[CH3:32][O:33][CH2:34][CH2:35][OH:36]>>[CH:29]1([C:26]([OH:28])([CH3:27])[CH2:25][NH:24][C:3](=[O:12])[C:4]2[CH:9]=[C:8]([C:17]3[CH:16]=[CH:15][C:14]([Cl:13])=[CH:19][C:18]=3[Cl:20])[C:7]([O:36][CH2:35][CH2:34][O:33][CH3:32])=[N:6][CH:5]=2)[CH2:31][CH2:30]1

Participants

5

Reactant 4

HCID 80192-MethoxyethanolHCID 2734659(2,4-Dichlorophenyl)boronic acidHCID 2764313Methyl 5-bromo-6-chloronicotinateHCID 211096921-Amino-2-cyclopropylpropan-2-ol

Product 1

HCID 11951299HCID 11951299, compound

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 11, using 5-bromo-6-chloro-nicotinic acid methylester, 2-methoxy-ethanol (commercially available), 2,4-dichlorophenyl-boronic acid (commercially available) and 1-amino-2-cyclopropyl-propan-2-ol (commercially available) as starting materials. MS (m/e): 439.3 (MH+).

Workup

  1. customdescribed for the preparation of Example 11

Sources & evidence

ORD record
ord-631935183c15486892783df235f6e584
Source dataset
uspto-grants-2007_06
Patent number
US07229999B2

Reaction notes

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