HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 11951475, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 21109712 | HCID 21109712 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 11951475 | HCID 11951475 | 68.8% |
Reaction Steps
A mixture of 16.2 mg (0.047 mmol) 6-benzylamino-5-(4-chloro-phenyl)-nicotinic acid, 19.6 mg (0.06 mmol) TBTU, 6.9 mg (0.06 mmol) (1R,2R)-2-amino-cyclohexanol and 23 mg (0.18 mmol) DIPEA in DMF was shaken at room temperature over night. Acetic acid was added and purified by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile/water/HCOOH. The combined product fractions were evaporated to yield 14.1 mg (55%) of the title compound. MS (m/e): 436.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-8f37005389dd4439823d9adf947125ce |
| Source note | uspto-grants-2007_06 |