HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R,2R)-2-Aminocyclohexanol → 5-Bromo-N-(trans-2-hydroxy-cyclohexyl)-6-(2-methoxy-ethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| Reactant | 5-Bromo-6-(2-methoxy-ethoxy)-nicotinic acid | HCID 21109705 | — |
| Product | 5-Bromo-N-(trans-2-hydroxy-cyclohexyl)-6-(2-methoxy-ethoxy)-nicotinamide | HCID 67505531 | — |
Reaction Steps
The title compound was synthesised in analogy to the amide coupling procedure described for the synthesis of Example 1, from 5-bromo-6-(2-methoxy-ethoxy)-nicotinic acid and trans-2-amino-cyclohexanol (commercially available). MS (m/e): 373.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-67f3c6511a0d4970a53c63f5bb8af98e |
| Source note | uspto-grants-2007_06 |