HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethanol → (RS)-5-(4-chloro-phenyl)-6-(2-methoxy-ethoxy)-N-(3,3,3-trifluoro-2-hydroxy-propyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethanol | HCID 8019 | — |
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | 3-Amino-1,1,1-trifluoropropan-2-ol | HCID 418965 | — |
| Reactant | Methyl 5-bromo-6-hydroxynicotinate | HCID 2764315 | — |
| Product | (RS)-5-(4-chloro-phenyl)-6-(2-methoxy-ethoxy)-N-(3,3,3-trifluoro-2-hydroxy-propyl)-nicotinamide | HCID 11951660 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 102, using 5-bromo-6-hydroxy-nicotinic acid methyl ester, 2-methoxyethanol, (4-chloro-phenyl)-boronic acid and 3-amino-1,1,1-trifluoro-propan-2-ol (CAS [431-38-9]) as starting materials to yield (RS)-5-(4-chloro-phenyl)-6-(2-methoxy-ethoxy)-N-(3,3,3-trifluoro-2-hydroxy-propyl)-nicotinamide. MS (ISP) 419.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-8ec38be207bc4663888feb629d7a5e8a |
| Source note | uspto-grants-2007_06 |