HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethanol → HCID 11951836, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethanol | HCID 8019 | — |
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | Methyl 5-bromo-6-hydroxynicotinate | HCID 2764315 | — |
| Reactant | HCID 53393211 | HCID 53393211 | — |
| Product | HCID 11951836 | HCID 11951836 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 102, using 5-bromo-6-hydroxy-nicotinic acid methyl ester, 2-methoxyethanol, (4-chloro-phenyl)-boronic acid and cis-2-aminomethyl-1-cyclohexanol hydrochloride as starting materials to yield racemic 5-(4-chloro-phenyl)-N-((1RS,2RS)-2-hydroxy-cyclohexylmethyl)-6-(2-methoxy-ethoxy)-nicotinamide. MS (ISP) 419.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-ace27fc9d934481f8eed99e487524c87 |
| Source note | uspto-grants-2007_06 |