4-Chlorophenylboronic acid → HCID 21109703, compound

HRID 1766505Notes

Reaction equation

HRID 1766505 reaction equation
Br[C:2]1[C:3]([N:11]([CH2:13][CH2:14][O:15][CH3:16])[CH3:12])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[Cl:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:2]2[C:3]([N:11]([CH2:13][CH2:14][O:15][CH3:16])[CH3:12])=[N:4][CH:5]=[C:6]([CH:10]=2)[C:7]([OH:9])=[O:8])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 21109706HCID 21109706, compound

Product 1

HCID 21109703HCID 21109703, compound

Procedure

In analogy to example 32c, 5-bromo-6-[(2-methoxy-ethyl)-methyl-amino]-nicotinic acid was reacted with 4-chlorophenylboronic acid to give 5-(4-chloro-phenyl)-6-[(2-methoxy-ethyl)-methyl-amino]-nicotinic acid as an off-white solid.

Sources & evidence

ORD record
ord-9cbd55b2c13d4d9e91964b1304182375
Source dataset
uspto-grants-2007_06
Patent number
US07229999B2

Reaction notes

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