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HRID1766513

反应详情

EQUATION

反应方程式

HRID 1766513 的结构方程式

REACTANTS

反应物

4
结构：OB(O)c1ccc(Cl)cc1
HCID74299

Benzeneboronic acid, p-chloro-

C6H6BClO2

结构：COC(=O)c1cnc(Cl)c(Br)c1
HCID2764313

Methyl 5-bromo-6-chloronicotinate

C7H5BrClNO2

结构：Cl.N[C@@H]1CCCC[C@H]1O
HCID12228412

未命名化合物

结构：CNCC1CC1.Cl
HCID12919210

未命名化合物

PRODUCTS

生成物

1
结构：CN(CC1CC1)c1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1
HCID11949889

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 74, using 5-bromo-6-chloro-nicotinic acid methyl ester, cyclopropylmethyl methylamine hydrochloride, (4-chloro-phenyl)-boronic acid and (1R,2R)-2-amino-cyclohexanol hydrochloride as starting materials to yield 5-(4-chloro-phenyl)-6-(cyclopropylmethyl-methyl-amino)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide. MS (ISP) 414.3 (M+H)+.

WORKUP

后处理

  1. customThe title compound was synthesized in analogy to Example 74