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HRID1766515

反应详情

EQUATION

反应方程式

HRID 1766515 的结构方程式

REACTANTS

反应物

4
反应SMILES：OB(O)c1ccc(F)cc1
HCID285645

4-Fluorophenylboronic acid

C6H6BFO2

反应SMILES：COC(=O)c1cnc(Cl)c(Br)c1
HCID2764313

Methyl 5-bromo-6-chloronicotinate

C7H5BrClNO2

反应SMILES：Cl.N[C@@H]1CCCC[C@H]1O
HCID12228412

未命名化合物

反应SMILES：CNCC1CC1.Cl
HCID12919210

未命名化合物

PRODUCTS

产物

1
反应SMILES：CN(CC1CC1)c1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(F)cc1
HCID11949891

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 74, using 5-bromo-6-chloro-nicotinic acid methyl ester, cyclopropylmethyl methylamine hydrochloride, (4-fluoro-phenyl)-boronic acid and (1R,2R)-2-amino-cyclohexanol hydrochloride as starting materials to yield 6-(cyclopropylmethyl-methyl-amino)-5-(4-fluoro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide. MS (ISP) 398.3 (M+H)+.

WORKUP

后处理

  1. customThe title compound was synthesized in analogy to Example 74